Chromoshadow domain search

Chromo shadow domain - Wikipedia

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In molecular biology, the chromo shadow domain is a protein domain which is distantly related to the chromodomain. It is always found in association with a chromodomain. Proteins containing a chromo shadow domain include Drosophila and human heterochromatin protein Su(var)205 (HP1); and mammalian modifier 1 and modifier 2.

Chromo shadow domain - Wikipedia

chromoshadow domain - oi

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Search for the text `chromoshadow domain' anywhere in Oxford Index » ...

chromoshadow domain - oi

Chromoshadow domain - Oxford Reference

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A domain (40–70 aa) found in some, but not all, proteins that have a chromodomain; it is involved in mediating dimerization, transcriptional repression, and interaction with multiple nuclear proteins. Related to the chromodomain.

Chromoshadow domain - Oxford Reference

Characterization of Chromoshadow Domain-mediated Binding ...

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5/25/2012 · Background: Heterochromatin protein 1 (HP1) is a non-histone chromatin protein that interacts with histone H3 through both the chromodomain and chromoshadow domain. Results: The chromoshadow domain specifically interacts with H3 residues located inside the nucleosome, close to the dyad. Conclusion: Rearrangement of the nucleosomal DNA is a prerequisite for binding.

Characterization of Chromoshadow Domain-mediated Binding ...

Mutations in Pdd1 Reveal Distinct Requirements for Its ...

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Mutations in Pdd1 Reveal Distinct Requirements for Its Chromodomain and Chromoshadow Domain in Directing Histone Methylation and Heterochromatin Elimination. ... A search for phosphorylatable residues in CD2 using the NetPhos (version 2.0) prediction software did not yield any potential candidates for modification, ...

Mutations in Pdd1 Reveal Distinct Requirements for Its ...

Characterization of Chromoshadow Domain-mediated Binding ...

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5/25/2012 · The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through interaction with histone H3. Here, we demonstrate the structural basis of this interaction for the CSD of HP1α. This mode of H3 binding is ...

Characterization of Chromoshadow Domain-mediated Binding ...

The Heterochromatin Protein 1 family | Genome Biology ...

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7/21/2006 · Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. The HP1 family is evolutionarily conserved, with members in fungi, plants and animals but not prokaryotes, and there are multiple members within the same species. The amino-terminal chromodomain binds methylated lysine 9 of …

The Heterochromatin Protein 1 family | Genome Biology ...

CBX5 (gene) - Wikipedia

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The N-terminal chromodomain and C-terminal chromoshadow domain appear to be much more conserved (approximately 50-70% amino acid similarity) than the hinge region (approximately 25-30% similarity with the Drosophila HP1 homolog). Interactions. CBX5 (gene) has been shown to interact with:

CBX5 (gene) - Wikipedia

Mutations in Pdd1 Reveal Distinct Requirements for Its ...

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2/1/2014 · A mutation in the chromoshadow domain (CSD) prevented Pdd1 focus formation but still permitted ∼17% of conjugants to produce viable progeny. However, this mutant was unable to stimulate excision when recruited to an ectopic IES, indicating that this domain is …

Mutations in Pdd1 Reveal Distinct Requirements for Its ...

Peptide recognition by heterochromatin protein 1 (HP1 ...

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4/7/2017 · Search by Keyword Author Year Vol Page Advanced Search ... Each of the three human homologs of HP1 includes a chromoshadow domain (CSD). The CSD interacts with various proteins bearing the PXVXL motif but also with a region of histone H3 that bears the similar PXXVXL motif. The latter interaction has not yet been resolved in atomic detail.

Peptide recognition by heterochromatin protein 1 (HP1 ...

LIA4 Encodes a Chromoshadow Domain Protein Required for ...

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10/1/2014 · HP1 forms homodimers via its chromoshadow domain (CSD) to form a critical protein interaction interface that serves as a scaffold to form heterochromatin . Heterochromatic regions are established in early stages of development, forming as early as the two-cell stage in mammalian embryos . Nevertheless, heterochromatin is not static and may ...

LIA4 Encodes a Chromoshadow Domain Protein Required for ...

Mutations of Pdd1 Chromo- and Chromoshadow Domains Reveal ...

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Loss of the entire chromoshadow domain: CSD) prevents nuclear targeting of Pdd1, while mutation of a single residue within the domain, I504D, reduces progeny production to ~5% and prevents Pdd1 foci formation and the recruitment of excision factors to an ectopic IES.

Mutations of Pdd1 Chromo- and Chromoshadow Domains Reveal ...

Somatic role of SYCE2: an insulator that dissociates HP1α ...

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6/1/2018 · Because both of the mutants contain the chromoshadow domain, this result suggests that SYCE2 may interact with the chromoshadow domain of HP1α. In support of this notion, the full-length FLAG-SYCE2 protein did not bind to the deletion mutant lacking the chromoshadow domain of HP1α . Then, we checked the region of SYCE2 that interacts with the ...

Somatic role of SYCE2: an insulator that dissociates HP1α ...

RCSB PDB - 5T1I: CBX3 chromo shadow domain in complex with ...

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Each of the three human homologs of HP1 includes a chromoshadow domain (CSD). The CSD interacts with various proteins bearing the PXVXL motif but also with a region of histone H3 that bears the similar PXXVXL motif. ... We consequently generalize the historical CSD-PXVXL interaction model and expand the search scope for additional CSD binding ...

RCSB PDB - 5T1I: CBX3 chromo shadow domain in complex with ...

Maintenance of Stable Heterochromatin Domains by Dynamic ...

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1/31/2003 · One function of heterochromatin is the epigenetic silencing by sequestration of genes into transcriptionally repressed nuclear neighborhoods. Heterochromatin protein 1 (HP1) is a major component of heterochromatin and thus is a candidate for establishing and maintaining the transcriptionally repressive heterochromatin structure. Here we demonstrate that maintenance of …

Maintenance of Stable Heterochromatin Domains by Dynamic ...

Peptide recognition by HP1 chromoshadow domains revisited ...

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Peptide recognition by HP1 chromoshadow domains revisited ...

Peptide recognition by HP1 chromoshadow domains revisited ...

(PDF) Characterization of Chromoshadow Domain-mediated ...

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PDF | The chromoshadow domain (CSD) of heterochromatin protein 1 (HP1) was recently shown to contribute to chromatin binding and transcriptional regulation through interaction with histone H3.

(PDF) Characterization of Chromoshadow Domain-mediated ...

RCSB PDB - 3Q6S: The crystal structure of the ...

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3Q6S: The crystal structure of the heterochromatin protein 1 beta chromoshadow domain complexed with a peptide from Shugoshin 1

RCSB PDB - 3Q6S: The crystal structure of the ...

chromoshadow domain : A Dictionary of Biomedicine - oi

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Show Summary Details Preview. A domain (40–70 aa) found in some, but not all, proteins that have a *chromodomain; it is involved. Reference Entry.

chromoshadow domain : A Dictionary of Biomedicine - oi

Selective interaction between the chromatin‐remodeling ...

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11/1/2002 · Mammalian heterochromatin protein 1 (HP1) α, HP1β and HP1γ are closely related non‐histone chromosomal proteins that function in gene silencing, presumably by organizing higher order chromatin structures. Here, we show by co‐immunoprecipitation that HP1α, but neither HP1β nor HP1γ, forms a complex with the BRG1 chromatin‐remodeling factor in HeLa cells.

Selective interaction between the chromatin‐remodeling ...

Selective interaction between the chromatin-remodeling ...

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Selective interaction between the chromatin-remodeling ...

chromo shadow domain binding - Wikidata

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Jump to navigation Jump to search. Interacting selectively and non-covalently with a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. ... chromoshadow domain binding; Statements. instance of. molecular function. 1 reference. stated in. Gene Ontology release 2019-02-07. retrieved.

chromo shadow domain binding - Wikidata

The histone methyltransferase SUV420H2 and Heterochromatin ...

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6/1/2009 · Interestingly, this domain of SUV420H2 contains a PYVRV sequence, which is similar to the pentameric sequences found through a phage display analysis with the Drosophila melanogaster HP1 chromoshadow domain and present in a number of proteins interacting to mammalian HP1 chromoshadow domains .

The histone methyltransferase SUV420H2 and Heterochromatin ...

The mammalian heterochromatin protein 1 binds diverse ...

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The HP1 proteins regulate epigenetic gene silencing by promoting and maintaining chromatin condensation. The HP1 chromodomain binds to methylated histone H3. More enigmatic is the chromoshadow domain (CSD), which mediates dimerization, transcription repression, and interaction with multiple nuclear ...

The mammalian heterochromatin protein 1 binds diverse ...

Binding of EMSY to HP1β: implications for recruitment of ...

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EMSY interacts with the chromoshadow domain of HP1β (HP1-CSD; Hughes-Davies et al, 2003).Deletion mapping narrowed the interaction site within EMSY to a region between residues 80 and 140, showing an HP1-binding consensus site adjacent to the ENT domain ().Mutagenesis of residues within the VxL motif of EMSY abolished the interaction with HP1-CSD (Hughes-Davies et al, 2003).

Binding of EMSY to HP1β: implications for recruitment of ...

ATRX ADD domain links an atypical histone methylation ...

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6/12/2011 · (a) Ribbon representation of ADD ATRX domain in complex with H3 1–15 K9me3 peptide. ADD ATRX domain is a hybrid of a GATA-like zinc finger …

ATRX ADD domain links an atypical histone methylation ...

Heterochromatin Protein 1, alpha (HP1a) Blocking Peptide ...

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Need Heterochromatin Protein 1, alpha (HP1a) Blocking Peptide for research? Find and compare commercial and governmental sources for immunological and biological products using the Linscott's Directory search engine. Locate proteins, assay kits, reagents, custom …

Heterochromatin Protein 1, alpha (HP1a) Blocking Peptide ...

Binding of EMSY to HP1β: implications for recruitment of ...

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7/1/2005 · Biophysical and nuclear magnetic resonance analyses show that the main complex formed by EMSY and the chromoshadow domain of HP1 (HP1‐CSD) consists of one EMSY dimer sandwiched between two HP1‐CSD dimers. The HP1β‐binding motif is necessary and sufficient for EMSY to bind to the chromoshadow domain of HP1β.

Binding of EMSY to HP1β: implications for recruitment of ...

Selective recognition of methylated lysine 9 on histone H3 ...

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3/1/2001 · Mutations of conserved residues in the HP1 chromo domain (V23M and KW41/42AA) abolish recognition of methylated H3, whereas mutation of a non-conserved residue (L68P) has …

Selective recognition of methylated lysine 9 on histone H3 ...

interplay between H2A.Z and H3K9 methylation in regulating ...

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7/11/2018 · Both the hinge region and the chromoshadow domain of HP1 proteins have been reported to interact with a number of targets, including DNA/RNA (18,19), linker histone H1 (20,21), the globular domain of H3 (22,23), and other HP1 molecules .

interplay between H2A.Z and H3K9 methylation in regulating ...

Oalib search

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Abstract: HP1 is a major component of chromatin and regulates gene expression through its binding to methylated histone H3.Most eukaryotes express at least three isoforms of HP1 with similar domain architecture. However, despite the common specificity for methylated histone H3, the three HP1 isoforms bind to different regions of the genome.

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